Besides kinds of CBD Vape Carts,There are still 7 common ways of CBD atomization?

--The technical post that helps you and me find out what to do:)

Besides all kinds of CBD vape carts,Fans have responded strongly to the CBD nebulization methods and are very interested in the best way to ingest and absorb CBD: How many ways are there to nebulize CBD? What are the modalities? And why is CBD heated nebulization the most suitable choice among the many nebulization methods and inhalation formulations?
Therefore, Dr. Hanyi specially asked the R&D team of Hanyi Biotechnology if they could introduce the current nebulization methods and inhalation formulations in detail from the pharmaceutical perspective.
Thus, we have today’s exclusive sharing.

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Episode:
There are 7 common ways of CBD nebulization, either by choosing one of the 3 common nebulization methods or by directly choosing one of the 4 common inhalation preparations.

  • Nebulization modalities include compression nebulization, ultrasonic nebulization, heated nebulization, etc.
  • Inhalation agents include inhalation powder mist, inhalation aerosol, inhalation spray, nebulized inhalation solution, etc.

Nebulization modalities

1. Compression atomization

Compression atomization is also called jet atomization. According to the venturi injection principle, compressed air is used to form a high-speed air flow through the small pipe orifice. The generated negative pressure drives the liquid or other fluids to spray onto the barrier together, splashes around under the high-speed impact, and makes the droplets turn into mist particles and eject from the air outlet pipe.

 

Medical compression atomizer shall meet the following requirements:

  • 1) Drugs are either aqueous or oil solutions, but most of them are aqueous solutions. If they are insoluble in water, they can         be made into oil solutions, but oil solutions as excipients have a great impact on the lungs;
  • 2) The particle size after atomization should also be less than 5um;
  • 3) The liquid medicine needs aseptic treatment.

CBD is soluble in MCT and other oil solutions. CBD oil is dispersed into fine particles below 10um by high-pressure air flow, which is inhaled by human body after deceleration. However, the experience of oil solution inhalation into the lungs is very poor, very choking, and may damage the lungs.

2、Ultrasonic atomization
Ultrasonic nebulization is the use of ultrasonic directional pressure, so that the surface of the liquid bulge, cavitation occurs around the bulging surface of the liquid, so that the liquid atomized into small molecules of aerosol. Ultrasonic nebulizer oscillation frequency of 1.7MHz or 2.4MHz, more than the range of human hearing, the electronic oscillation of human and animal harmless, the device through the ceramic atomization piece of high-frequency resonance, the liquid water molecular structure to break up and produce a natural floating water mist. In addition, the atomization process will release a large number of negative ions, which will produce electrostatic reaction with the smoke and dust floating in the air and make it precipitate.

If the drug to achieve ultrasonic nebulization need to have the following prerequisites.

  • 1) must be water soluble, if not water soluble need to add surfactant or emulsifier, so that the drug dissolved in aqueous solution before ultrasound.
  • 2) the aerosolized fluid inhaled via the lungs needs to be sterile and technically difficult.
  • 3) The particle size of the aerosolized water mist needs to be less than 5um, which needs to be studied in combination with the drug.

CBD ultrasonic nebulization products are mostly conceptual hydration cosmetics, 1mg CBD can be solubilized into 1-3ml water solution, the nebulization time is 30min, and because of the solubilization to join a large number of excipients, the inhalation experience is extremely poor.

Most commercially available products are cosmetic hydration products, which do not play a therapeutic role.

3、Heating nebulization

Heating nebulization, the principle is to heat the drug directly, so that it sublimates into a gas for inhalation. The most used in medicine for anesthetics, enflurane, isoflurane, sevoflurane, etc., by direct heating to produce aerosols, inhaled to achieve the effect of general anesthesia or local anesthesia.

In recent years, there are also cases of products like CCELL, KRT,TKO,Such as the products in store of ecigcarts.com, etc., where the slightly higher boiling point of loxapine and other substances are formed into drugs.

CBD atomization products on the market are mostly e-cigarettes, whose boiling point is between 410-500 ℃, loxapine boiling point of 458 ℃. CBD heating atomization into drugs is possible, but need to work on the design and precise coordination of the heating system and atomization system.

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Nate Diaz, a famous boxer, once publicly smoked an electronic cigarette. "This is CBD cigarette oil, which makes me recover faster and has a therapeutic effect on some inflammation. I smoke some before and after the game, which makes people feel good."

Inhaled preparations (4 common preparations shared)

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1、Inhalation powder nebulizer

Inhalation powder nebulizer refers to the preparation of micronized drug or with carrier in the form of capsule, vesicle or multi-dose storage, using a special dry powder inhalation device, the patient actively inhaled nebulized drug to the lungs.

Inhalation powder nebulizers have the following characteristics.

  • 1) the drug or the addition of excipients (mostly lactose) can be micronized into particles of about 5um.
  • (2) The particles are not easy to absorb moisture or agglomerate, and can be evenly attached to the trachea and bronchial tubes after inhalation, or directly absorbed by the alveoli.

CBD powder is very easy to agglomerate, the experiment is by ball milling, water-liquid ball milling, airflow crushing, etc. can reach a particle size of about 20um, it is difficult to meet the requirements of inhalation preparations.

2、Inhalation aerosol

Aerosol refers to the drug-containing solution, emulsion or suspension with a suitable projectile together in a pressure-resistant container with a special valve system, when used with the pressure of the projectile will be sprayed into a mist of the contents, inhaled to play a local or systemic therapeutic effect. According to the composition of prescription, aerosols can be divided into: solution type, emulsion type and suspension type aerosols.

According to the different excipients in the prescription, it can be roughly divided into four types.

  • 1) drug, throwing agent system.
  • 2) Drug, co-solvent, and throwing agent system.
  • 3) drug, surfactant, projectile agent system.
  • 4) drug, surfactant, co-solvent, and projectile agent systems. Commonly used throwing agents are hydrofluorinated alkanes (HFA) such as tetrafluoroethane (HFA134a) and heptafluoropropane (HFA227).

It is common to use one or several projectile agents in combination in the prescription.

CBD is highly hydrophobic and needs to be made into a spray with a surface activator or co-solvent. CBD is almost insoluble in the projectile and needs to be solubilized with the help of ethanol. The drug loading capacity is extremely low.

3、Inhalation spray

According to the prescription composition of the spray can be divided into: solution type, emulsion type and suspension type. The composition of the prescription of the spray and aerosol, in addition to the absence of a projectile, the composition is basically the same. Spray generally consists of drugs, solvents, co-solvents, surfactants, and sometimes stabilizers are added according to the different physical and chemical properties of drugs. If preservatives are used, attention should be paid to their impact on safety.

The application of CBD in inhalation sprays is similar to that of aerosols, and there are problems such as low drug loading and difficulty in controlling particle size.

4、Nebulized inhalation solution

Nebulized inhalation solution is a drug configured as an aqueous or oil solution, which is nebulized into small droplets below 5um using the pressurized or ultrasonic nebulizer described above. It will usually be used in combination with a nebulizer.

CBD to be made into a nebulized inhalation solution requires the addition of a large amount of epi-activator or oil solution with a low drug loading capacity and a high impact on the lungs after inhalation.

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So here comes the question…,

Which atomization method or inhalation preparation is the best for CBD in vivo intake and absorptionIn 

summary
CBD is most likely to be delivered by heated nebulization, but requires work on the design and precise coordination of the heating system and the nebulization system. If there is a product that can be designed specifically for the boiling and dissolving point of CBD, and the equipment also combines with the drug properties of CBD itself, in order to enhance the bioavailability of CBD through nebulization equipment, and at the same time realize the innovation of combining formulation science and equipment technology, then countless people who need CBD will see a new hope!

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